Onkar B. Patil¹, Swarupa N. Shirke²
, Arehalli S. Manjappa¹
, Popat S. Kumbhar¹
John I. Disouza¹
¹Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist. Kolhapur, Maharashtra-416113, India
²Shree Santkrupa College of Pharmacy, Shivajinagar, Ghogaon, Maharashtra, India.
Corresponding author: obpatil.tkcp@gmail.com
Received: July 11, 2022/ Revised: Aug 18, 2022 / Accepted: Aug 20, 2022
Abstract
Transdermal drug delivery systems (TDDS) are used to transfer medicines into the systemic circulation through the skin. (Trans)dermal patches are well-known pharmacological formulations that are applied to the skin’s surface for a variety of reasons, ranging from treating cutaneous diseases to achieving a systemic impact. Transdermal drug delivery (TDD) devices rely heavily on adhesives. In addition to the normal functional adhesive qualities, adhesives for TDD applications must be biocompatible with the skin, chemically compatible with the medication, and enable consistent, efficient drug administration. One of the most important components of a TDDS is the pressure-sensitive adhesive (PSA). PSA’s primary role is to aid patch adherence to the skin, but it also serves as a matrix for the medication and other excipients. As a result, PSA impacts other important quality aspects of the TDDS, such as drug distribution, flux through skin, and physical and chemical stability of the completed product, in addition to patch adherence. This article addresses transdermal drug delivery systems, their benefits and drawbacks, and their uses in pharmaceuticals, as well as providing detailed information on pressure sensitive adhesives.
Keywords Transdermal drug delivery; Adhesives; Pressure sensitive adhesives; pharmaceutical applications
References
Ameena, D., Michniak-Kohn, B. (2019). Development and in vitro evaluation of pressure sensitive adhesive patch for the transdermal delivery of galantamine: Effect of penetration enhancers and crystallization inhibition. European Journal of Pharmaceutics and Biopharmaceutics, 139, 262–271.
Banerjee, S., Chattopadhyay, P., Ghosh, A., Datta, P., & Veer, V. (2014). Aspect of adhesives in transdermal drug delivery systems. International Journal of Adhesion and Adhesives, 50, 70-84.
Barnhart, S. (1998). Critical Role of PSA in Transdermal Drug Delivery. Adhesives and Sealants Industry, MI, USA 1–6.
Benedek, I., Heymans, L.J. (1997) Pressure Sensitive Adhesive Technology. Mercel Dekker, NY, USA.
Cilurzo, F., Selmin, F., Gennari, C. G., Montanari, L., & Minghetti, P. (2014). Application of methyl methacrylate copolymers to the development of transdermal or loco-regional drug delivery systems. Expert opinion on drug delivery, 11(7), 1033-1045.
Dasht Bozorg, B., & Banga, A. K. (2020). Effect of different pressure-sensitive adhesives on performance parameters of matrix-type transdermal delivery systems. Pharmaceutics, 12(3), 209.
Ganti, S. S., Bhattaccharjee, S. A., Murnane, K. S., Blough, B. E., & Banga, A. K. (2018). Formulation and evaluation of 4-benzylpiperidine drug-in-adhesive matrix type transdermal patch. International journal of pharmaceutics, 550(1-2), 71-78.
Higgins, J.J., Jagisch, F.C., Stucker, N.E. (1989) Handbook of Pressure Sensitive Adhesive Technology. Van Nostrand Reinhold, NY, USA.
Lobo, S., Sachdeva, S., & Goswami, T. (2016). Role of pressure-sensitive adhesives in transdermal drug delivery systems. Therapeutic delivery, 7(1), 33-48.
Musazzi, U. M., Ortenzi, M. A., Gennari, C. G., Casiraghi, A., Minghetti, P., & Cilurzo, F. (2020). Design of pressure-sensitive adhesive suitable for the preparation of transdermal patches by hot-melt printing. International Journal of Pharmaceutics, 586, 119607.
Musolf, MC. (1987). Transdermal Controlled Systemic Medications. Marcel Dekker, NY, USA (1987).
Peterson, T.A., Wick, S.M., Ko, C. (1997). Transdermal and Topical drugdelivery systems. Interpharm Press,IL, USA.
Pfister, W. R., Woodard, J. T., & Grigoras, S. (1992). Developing drug-compatible adhesives for transdermal drug delivery devices. Pharmaceutical technology, 16(1).
Satas, D. (1989). Handbook of Pressure Sensitive Adhesive Technology. Van Nostrand Reinhold, NY, USA.
Tan, H. S., & Pfister, W. R. (1999). Pressure-sensitive adhesives for transdermal drug delivery systems. Pharmaceutical Science & Technology Today, 2(2), 60-69.
Temin, S.C. (1990) Handbook of Adhesives (3rd Edition). Van Nostrand Reinhold, NY, USA.
Yang, D., Wan, X., Quan, P., Liu, C., & Fang, L. (2018). The role of carboxyl group of pressure sensitive adhesive in controlled release of propranolol in transdermal patch: Quantitative determination of ionic interaction and molecular mechanism characterization. European Journal of Pharmaceutical Sciences, 115, 330-338.
How to cite this article
Patil, O.P., Shirke, S.N., Manjappa, A.S., Kumbhar, P.S. and Disouza, J.I. (2022). Pressure sensitive adhesives in transdermal drug delivery system. Chemical and Environmental Science Archives, Vol. 2 (3), 17-21. http://dx.doi.org/10.47587/CESA.2022.2301
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